High Entropy Alloys for metallic biomaterials (BioHEAs)

High Entropy Alloys for metallic biomaterials (BioHEAs)


Figure 1 Mechanical properties and biocompatibility in TiNbTaZrMo HEAs [1]

A novel equiatomic TiNbTaZrMo high-entropy alloy (HEA) was developed as a new metallic biomaterial. The constituent elements of the HEA were biocomparable, and the HEA was designed based on parameters for predicting solid solution phase in complex, concentrated alloys (CCAs). The bcc solid solution phases with the different lattice constants were obtained in as-cast and annealed states. The HEA showed considerable strength with deformability and superior biocompatibility comparable to pure Ti.


  1. 永瀬丈嗣, 中野貴由, ハイエントロピー合金, "7.3章 生体材料", 乾晴行 編集, 内田老鶴圃, (2020), pp. 240-246., ISBN 978-4-7536-5137-5, http://www.rokakuho.co.jp/data/books/5137.html


  1. Y. Iijima, T. Nagase, A. Matsugaki, P. Wang, K. Ameyama, T. Nakano, Materials & Design, 202, 109548 (2021)., "Design and development of Ti-Zr-Hf-Nb-Ta-Mo High-Entropy Alloys for Metallic Biomaterials", https://doi.org/10.1016/j.matdes.2021.109548
  2. T. Ishimoto, R. Ozasa, K. Nakano, M. Weinmann, C. Schnitter, M. Stenzel, A. Matsugaki, T. Nagase, T. Matsuzaka, M. Todai , H. S. Kim, T. Nakano, Scripta Materialia, 194, 113658 (2021)., "Development of TiNbTaZrMo bio–high entropy alloy (BioHEA) super–solid solution by selective laser melting, and its improved mechanical property and biocompatibility", https://doi.org/10.1016/j.scriptamat.2020.113658
  3. T. Nagase, Y. Iijima, A. Matsugaki, K. Ameyama, T. Nakano, Mater. Sci. Eng. C, 107, 110322 (2020)., "Design and fabrication of Ti-Zr-Hf-Cr-Mo and Ti-Zr-Hf-Co-Cr-Mo high-entropy alloys as metallic biomaterials", https://doi.org/10.1016/j.msec.2019.110322
  4. T. Hori, T. Nagase, M. Todai, A. Matsugaki, T. Nakano, Scripta Materialia, 172, 83-87 (2019)., "Development of Non-equiatomic Ti-Nb-Ta-Zr-Mo High-Entropy Alloys for Metallic Biomaterials", https://doi.org/10.1016/j.scriptamat.2019.07.011
  5. T. Nagase, K. Mizuuchi, T. Nakano, Entropy, 21, 483 1-17 (2019), "Solidification microstructures of the ingots obtained by arc melting and cold crucible levitation melting in TiNbTaZr medium-entropy alloy and TiNbTaZrX (X = V, Mo, W) high-entropy alloys", https://doi.org/10.3390/e21050483
  6. T. Nagase, M. Todai, T. Hori, T. Nakano, Journal of Alloys and Compounds, 753, 412-421 (2018)., "Microstructure of equiatomic and non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials", https://doi.org/10.1016/j.jallcom.2018.04.082
  7. M. Todai, T. Nagase, T. Hori, A. Matsugaki, A. Sekita, T. Nakano, Scripta Materialia, 129, 65-68 (2017)., "Novel TiNbTaZrMo high-entropy alloys for metallic biomaterials", http://dx.doi.org/10.1016/j.scriptamat.2016.10.028

REFERENCES (Review paper)

  1. 小笹良輔, 松垣あいら, 當代光陽, 石本卓也, 永瀬丈嗣, 中野貴由, チタン, 70, 44-52 (2022)., "チタン含有生体用ハイエントロピー合金の研究・開発", https://ci.nii.ac.jp/ncid/AN10468673
  2. 當代光陽, 永瀬丈嗣, 中野貴由, 軽金属, 70, 14-23 (2020)., "軽金属元素を含むハイエントロピー合金とBCC型生体用ハイエントロピー合金の開発と展望", https://doi.org/10.2464/jilm.70.14
  3. 當代光陽, 永瀬丈嗣, 中野貴由, チタン, 68, 59-63 (2020)., "純チタンに匹敵する生体適合性を有する生体用bcc型ハイエントロピー合金の設計と開発", http://www.titan-japan.com/
  4. 中野貴由, 永瀬丈嗣, 當代光陽, 月刊BIO INDUSTRY, Vol. 34, No. 5, 8-20 (2017)., "生体用高強度ハイエントロピー合金の開発", https://www.cmcbooks.co.jp/products/detail.php?product_id=5266


  1. 2020/01/29 「適合性高く高強度 インプラント向け合金」 日刊工業新聞
  2. 2019/08/05 人工骨など向け高強度の新合金, 日経新聞
  3. 2016/11/30 「阪大、チタンより固い生体合金開発 強度1.7倍、人工関節用に」 日刊工業新聞

トップ   編集 凍結解除 差分 履歴 添付 複製 名前変更 リロード   新規 一覧 検索 最終更新   ヘルプ   最終更新のRSS
Last-modified: 2022-02-01 (火) 12:06:00